Combination pharmacotherapy remains an important modality for the treatment of neuropathic pain in adults. However, as monotherapy current drugs are associated with limited efficacy and dose-related side effects. Combining two or more different drugs may improve analgesic efficacy and, in some situations, reduce overall side effects (e.g. if synergistic interactions allow for dose reductions of combined drugs).
This review evaluated the efficacy, tolerability and safety of various drug combinations for the treatment of neuropathic pain. Multiple, good-quality studies demonstrate superior efficacy of two-drug combinations.
Read the full study here: http://www.ncbi.nlm.nih.gov/pubmed/22786518